Pregnancy Maternal Infection as Childhood Leukemia Risk Factor: A Systematic Review

Ilma Syifannisa

Authors

Ilma Syifannisa Swadaya Gunung Jati University

Keywords:

Maternal infection, pregnancy, childhood leukemia

Abstract

One of the most prevalent form of cancer in the pediatric population was leukemia. The initiation of childhood leukemia could possibly occur during the fetal stage, as evidenced by the presence of leukemia-associated chromosomal abnormalities at birth. The occurrence of maternal infection while pregnant is common and has the potential to induce chromosomal or immunological changes in the developing fetus, thereby increasing the likelihood of childhood leukemia. The main objective of this research is to identify a relationship between maternal infection during pregnancy and childhood leukemia. To achieve this aim, a systematic review was carried out that encompassed publications released between 2013 and 2023, sourced from various online databases including Pubmed and SagePub. There are total of 55 articles on PubMed and 73 articles on SagePub. Following the screening of titles, five studies meeting the predetermined criteria were included. The study's main discovery confirms that maternal infection during pregnancy is a possible risk factor for childhood leukemia. The transmission of infectious agents with oncogenic properties from mother to fetus may result in genomic instability.

Downloads

Download data is not yet available.

References

Bonaventure, A., Kane, E., Simpson, J., & Roman, E. (2023). Maternal infections and medications in pregnancy: how does self-report compare to medical records in childhood cancer case–control studies? International Journal of Epidemiology, 52(4), 1187–1196. https://doi.org/10.1093/ije/dyad019

Da Rocha Paiva Maia, R., & Filho, V. W. (2013). Infection and childhood leukemia: Review of evidence. Revista de Saude Publica, 47(6), 1172–1185. https://doi.org/10.1590/S0034-8910.2013047004753

Flores-Lujano, J., Perez-Saldivar, M. L., Fuentes-Pananá, E. M., Gorodezky, C., Bernaldez-Rios, R., Del Campo-Martinez, M. A., Martinez-Avalos, A., Medina-Sanson, A., Paredes-Aguilera, R., De Diego-Flores Chapa, J., Bolea-Murga, V., Rodriguez-Zepeda, M. C., Rivera-Luna, R., Palomo-Colli, M. A., Romero-Guzman, L., Perez-Vera, P., Alvarado-Ibarra, M., Salamanca-Gómez, F., Fajardo-Gutierrez, A., & Mejía-Aranguré, J. M. (2009). Breastfeeding and early infection in the aetiology of childhood leukaemia in down syndrome. British Journal of Cancer, 101(5), 860–864. https://doi.org/10.1038/sj.bjc.6605244

Gallant, R. E., Arroyo, K., Metayer, C., Kang, A. Y., de Smith, A. J., & Wiemels, J. L. (2023). Associations between early-life and in utero infections and cytomegalovirus-positive acute lymphoblastic leukemia in children. International Journal of Cancer, 152(5), 845–853. https://doi.org/10.1002/ijc.34292

He, J. R., Hirst, J. E., Tikellis, G., Phillips, G. S., Ramakrishnan, R., Paltiel, O., Ponsonby, A. L., Klebanoff, M., Olsen, J., Murphy, M. F. G., Håberg, S. E., Lemeshow, S., F Olsen, S., Qiu, X., Magnus, P., Golding, J., Ward, M. H., Wiemels, J. L., Rahimi, K., … Dwyer, T. (2022). Common maternal infections during pregnancy and childhood leukaemia in the offspring: Findings from six international birth cohorts. International Journal of Epidemiology, 51(3), 769–777. https://doi.org/10.1093/ije/dyab199

He, J. R., Yu, Y., Fang, F., Gissler, M., Magnus, P., László, K. D., Ward, M. H., Paltiel, O., Tikellis, G., Maule, M. M., Qiu, X., Du, J., Valdimarsdóttir, U. A., Rahimi, K., Wiemels, J. L., Linet, M. S., Hirst, J. E., Li, J., & Dwyer, T. (2023). Evaluation of Maternal Infection During Pregnancy and Childhood Leukemia Among Offspring in Denmark. JAMA Network Open, 6(2), e230133. https://doi.org/10.1001/jamanetworkopen.2023.0133

Hjorth, S., Pottega, A., Broe, A., Hemmingsen, C. H., Leinonen, M. K., & Hargreave, M. (2022). study in four Nordic countries. October 2021, 778–788.

Jia, M. (2017). 乳鼠心肌提取 HHS Public Access. Physiology & Behavior, 176(3), 139–148. https://doi.org/10.1016/j.ajog.2020.08.053.Endometrial

Kumar, A., Vashist, M., & Rathee, R. (2014). Maternal factors and risk of childhood leukemia. Asian Pacific Journal of Cancer Prevention, 15(2), 781–784. https://doi.org/10.7314/APJCP.2014.15.2.781

Metayer, C., Dahl, G., Wiemels, J., & Miller, M. (2016). Childhood Leukemia: A preventable disease. Pediatrics, 138(November 2016), S45–S55. https://doi.org/10.1542/peds.2015-4268H